Glutathione and tranexamic acid: the gentle answer to dark spots
Last updated 12 October 2026
Post acne marks and sun spots are among the most common reasons people start a serious routine. Strong vitamin C works for many, but not everyone tolerates it. Korean brands increasingly rely on gentler brightening ingredients. Here is what they do and how to build a routine around them.
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Why dark spots form
Dark spots are areas where the skin produces more melanin than its surroundings. Triggers are UV light, inflammation after a breakout and hormonal changes. The marks left behind after acne are called post inflammatory hyperpigmentation.
Because UV keeps stimulating melanin, no brightening product works without daily sunscreen. That is the most important step of the whole routine.
Why gentler ingredients
Pure vitamin C at high concentrations is effective but can sting, especially on sensitive or atopic skin. K Beauty often combines several milder brightening ingredients at moderate levels instead.
The goal is steady, tolerable use over months. A product you can apply every day without irritation usually beats a stronger one you have to pause.
The key ingredients
Tranexamic acid (TXA) is known from dermatology for its use against melasma and helps calm the signals that drive excess pigment.
Glutathione is an antioxidant that is marketed for brightening. Evidence for topical use is more limited than for the other ingredients here, so see it as a supporting player.
Niacinamide reduces the transfer of pigment to the upper skin layers and also supports the barrier.
Alpha arbutin is a gentler relative of hydroquinone and slows melanin production.
Products in this guide
Numbuzin No.5+ Glutathione TXA Advanced Dark Spot Ampoule Concentrate combines glutathione and tranexamic acid and is meant for targeted use on marks.
Numbuzin No.5 Goodbye Blemish Serum is a lighter all over serum for uneven tone.
Beauty of Joseon Glow Deep Serum Rice + Alpha Arbutin is a mild, affordable option with arbutin and niacinamide that suits beginners.
Numbuzin No.5+ Glutathione Vitamin Concentrated Toner Pads can be laid on marks for a few minutes as a prep step.
A simple routine
Morning: gentle cleanser, brightening serum, moisturiser, sunscreen SPF 50.
Evening: cleanse, optional brightening pad as a soak, ampoule or serum, moisturiser.
Introduce one new product at a time and give each at least two weeks before judging how your skin reacts.
How long it really takes
Fresh post acne marks often fade noticeably within six to twelve weeks of consistent use. Older sun spots and melasma take longer and often need a dermatologist.
If a spot changes shape, colour or size, have it checked by a doctor before treating it cosmetically.
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Products in this guide
Prices, ratings and short verdicts from our database, linked to the full product page.

numbuzin
No.5 Goodbye Blemish Serum
from €25.00★ 3.9 (25)
A lightweight No.5 serum built around niacinamide, a vitamin C derivative and panthenol, aimed at fading post blemish marks and evening out tone.

numbuzin
No.5+ Glutathione TXA Advanced Dark Spot Ampoule Concentrate
A small, concentrated No.5+ ampoule that pairs glutathione with tranexamic acid and niacinamide for targeted care of dark spots and dull, uneven tone.

numbuzin
No.5+ Glutathione Vitamin Concentrated Toner Pads
Toner pads soaked in glutathione, vitamin C and niacinamide with mild PHA and LHA, for a brighter, more even look. 70 pads per jar.
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